The Saints quarterback surpassed Brett Favre after throwing for three first-half scores in his team’s 51-14 win, taking his career tally to 509.
Brees threw two touchdowns to wide receiver Michael Thomas, with a 28-yard strike to running back Mark Ingram sandwiched in between.
The 39-year-old also scored himself, diving in from a yard out in the third quarter as in-form New Orleans registered an eighth successive victory.
Peyton Manning - who managed 539 touchdown passes in his illustrious career - is the all-time leader.
Brees surpassed Manning’s previous record of 71,940 yards in a Week 5 victory over the Washington Redskins, having already exceeded Favre’s mark of 6,300 career completions.
He became the NFL’s all-time passing leader in Week 5, surpassing Peyton Manning’s previous record of 71,940 yards with a 62-yard touchdown pass to Tre’Quan Smith against the Redskins.
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